If you're setting up a new Fediverse server, you may run into technical difficulties if you re-use a subdomain or domain from a server that has now closed. More info about this at:
TL:DR - You can avoid technical problems by always using a brand new subdomain whenever you set up a new Fediverse server. It's okay to be the subdomain of a previously used domain, as long as the subdomain itself is new.
@homegrown unless the main domain is widely blocked by other Fedi instances for whatever reason, then all subdomains will be blocked.